(Red wine may be much more potent than was thought in extending human life-span, researchers say in a report that is likely to give impetus to the rapidly growing search for longevity drugs.
The recent study is based on dosing mice with resveratrol, an ingredient of some red wines. Some scientists are already taking resveratrol in capsule form but others believe it is far too early to take the drug, especially using wine as its source, until there is better data on its safety and effectiveness.
The report is part of a new wave of interest in drugs that may enhance longevity. On June 2, Sirtris, a startup founded in 2004 to develop drugs with the same effects as resveratrol, completed its sale to GlaxoSmithKline for $720 million.
Sirtris is seeking to develop drugs that activate protein agents known in people as sirtuins. "The upside is so huge that, if we are right, the company that dominates the sirtuin space could dominate the pharmaceutical industry and change medicine," David Sinclair of Harvard Medical School, a co-founder of the company, said Tuesday.
Serious scientists have long derided the idea of life-extending elixirs, but the door has now been opened to drugs that exploit an ancient biological survival mechanism, that of switching the body's resources from fertility to tissue maintenance. The improved tissue maintenance seems to extend life by cutting down on the degenerative diseases of aging.)
http://www2.tbo.com/content/2008/jun/13/na-red-wine-ingredient-shows-promise-against-aging/